PRF (Platelet-Rich Fibrin)

Platelet-Rich Fibrin (PRF) is a second-generation platelet concentrate that has gained significant importance in dentistry and oral surgery. Unlike Platelet-Rich Plasma (PRP), PRF is prepared without anticoagulants or biochemical additives, making it a natural and biocompatible material. The technique involves drawing a small amount of the patient’s venous blood, which is immediately centrifuged. This process results in the formation of a fibrin clot rich in platelets, leukocytes, and growth factors. The clot can then be shaped into a membrane or plug for clinical use.

The biological advantages of PRF are attributed to its composition. The fibrin matrix acts as a scaffold that entraps and gradually releases growth factors such as platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), and transforming growth factor beta (TGF-β). These molecules stimulate angiogenesis, cell proliferation, and tissue regeneration. The leukocytes present in PRF contribute to immune modulation and may provide antibacterial effects, further supporting wound healing.

In clinical dentistry, PRF is widely used to enhance bone regeneration in sinus lift procedures, ridge augmentations, and implant surgeries. Following tooth extractions, it is placed into the socket to reduce complications like dry socket and accelerate healing. In periodontology, PRF has been applied in the management of intrabony defects and gingival recessions, with promising results.

Overall, PRF is a safe, autologous, and cost-effective regenerative tool. By harnessing the patient’s own biological resources, it enhances healing and continues to play an increasingly important role in modern dental practice.